References

Adams, M.D., Kelley, J.M., Gocayne, J.D., Dubnick, M., Polymeropoulos, M.H., Xiao, H., Merril, C.R., Wu, A., Olde, B., Moreno, R.F., Kerlavage, A.R., McCombie, W.R., and Venter, J.C. (1991). Complementary DNA sequencing: Expressed sequence tags and human genome project, Science, 252:1651-56.

Adams, M.D., Dubnick, M., Kerlavage, A.R., Moreno, R. Kelley, J.M., Utterback, T.R., Nagle, J.W., Fields, C., and Venter, J.C. (1992). Sequence of 2,375 human brain genes. Nature. 355:632-634.

Adams, M.D., Kerlavage, A.R., Fields, C., and Venter, J.C. (1993a). 3400 new expressed sequence tags identify diversity of transcripts in human brain. Nature Genetics 4:256-267.

Adams, M.D., Kerlavage, A.R., Kelley, J.M., Gocayne, J.D., Fields, C., Fraser, C.M., and Venter, J.C. (1994). A model for high-throughput automated DNA sequencing and analysis core facilities. Nature 368:474-475.

Adams, M.D., Kerlavage, A.R., Fleischmann, R.D., Fuldner, R.A., Bult, C.J., Lee, N.H., Kirkness, E.F., Weinstock, K.G., Gocayne, J.D., White, O., Sutton, G., Blake, J.A., Brandon, R.C., Chiu, M.W., Clayton, R.A., Cline, R.T., Cotton, M.D., Earle-Hughes, J., Fine, L.D., FitzGerald, L.M., FitzHugh, W.M., Fritchman, J.L., Geoghagen, N.S.M., Glodek, A., Gnehm, C.L., Hanna, M.C., Hedblom, E., Hinkle, P.S. Jr, Kelley, J.M., Klimek, K.M., Kelley, J.C., Liu, L.-I., Marmaros, S.M., Merrick, J.M., Moreno-Palanques, R.F., McDonald, L.A., Nguyen, D.T, Pellegrino, S.M., Phillips, C.A., Ryder, S.E., Scott, J.L., Saudek, D.M., Shirley, R., Small, K.V., Spriggs, T.A., Utterback, T.R., Weidman, J.F., Li, Y., Barthlow, R., Bednarik, D.P., Cao, L., Cepeda, M.A., Coleman, T.A., Collins, E.-J., Dimke, D., Feng, P., Ferrie, A., Fischer, C., Hastings, G.A., He, W.-W., Hu, J.-S., Huddleston, K.A., Greene, J.M., Gruber, J., Hudson, P., Kim, A., Kozak, D.L., Kunsch, C., Ji, H., Li, H., Meissner, P.S., Olsen, H., Raymond, L., Wei, Y.-F., Wing, J., Xu, C., Yu, G.-L., Ruben, S.M., Dillon, P.J., Fannon, M.R., Rosen, C.A., Haseltine, W.A., Fields, C., Fraser, C.M. and Venter, J.C. (1995). Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. Nature, 377 (Suppl.):3-174.

Adams, M.D., Soares, M.B., Kerlavage, A.R., Fields, C., and Venter, J.C. (1993b). Rapid cDNA sequencing (Expressed Sequence Tags) from a directionally cloned human infant brain cDNA library. Nature Genetics 4:373-380.

Aduse-Opuku, J., Muir, J. , Slaney, J.M., Rangarajan, M. , and Curtis, M.A. (1995). Characterization, genetic analysis and expression of a protease antigen (Prp R1) of Porphyromonas gingivalis W50. Infect. Immun. 63: 4744-4754.

Ali, R.W., Lie, T., and Skaug, N. (1992). Early effects of periodontal therapy on the detection frequency of four putative periodontal pathogens in adults. J. Periodontol. 63: 540-547.

Altschul, S., Gish, W., Miller, W., Myers, E., and Lipman, D. (1990). Basic alignment search tool. J. Mol. Biol. 215:403-410.

Blaisdell, B.E., Rudd, K.E., Matin, A., and Karlin, S. (1993). Significant dispersed recurrent DNA sequences in Escherichia coli genome. Several new groups. J. Mol. Biol. 229:833-848.

Barkocy-Gallagher, G.A., Han, N., Patti, J.M., Whitlock, J., Progulske-Fox, A., and Lantz, M.S. (1996). Analysis of the prtP gene encoding porphypain, a cysteine proteinase of Porphyromonas gingivalis. J. Bacteriol. 178: 2734-2741.

Borodovsky, M. and McIninch, J. (1993). GeneMark: Parallel gene recognition for both DNA strands. Comp. Chem. 17:123.

Bramanti, T.E., and Holt, S.C. (1990). Iron-regulated outer membrane proteins in the periodontopathic bacterium, Bacteroides gingivalis. Biochem. Biophys. Res. Commun. 166: 1146-1154.

Bramanti, T.E., and Holt, S.C. (1991). Roles of porphyrins and host iron transport proteins in regulation of growth of Porphyromonas gingivalis W50. J. Bacteriol. 173: 7330-7339.

Bramanti, T.E., and Holt, S.C. (1992). Localization of a Porphyromonas gingivalis 26-kilodalton heat-modifiable, hemin-regulated surface protein which translocates across the outer membrane. J. Bacteriol. 174: 5827-5839.

Bramanti, T.E., and Holt, S.C. (1993). Hemin uptake in Porphyromonas gingivalis: Omp26 is a hemin-binding surface protein. J. Bacteriol. 175: 7413-7420.

Brutlag, D.L., Dautricourt, J.P., Diaz, R., Fier, J., Moxon, B., and Stamm, R. (1993).BLAZE: an implementation of the Smith-Waterman sequence comparison algorithm on a massively parallel computer. Comp. Chem. 17:203-207.

Bult, C.J., White, O., Olsen, G.J., Zhou,L., Fleischmann, R.D., Sutton, G.G., Blake, J.A., FitzGerald, L.M., Clayton, R.A., Gocayne, J.D., Kerlavage, A.R., Dougherty, B.A., Tomb, J.-F., Adams, M.D.,Reich, C.I., Overbeek, R., Kirkness, E.F., Weinstock, K.G., Merrick, J.M., Glodek, A.,Scott, J.L., Geoghagen, N.S.M., Weidman, J.F., Fuhrmann, J.I., Nguyen, D.T, Utterback, T.R., Kelley, J.M., Peterson, J.D., Sadow, P.W., Hanna, M.C., Cotton, M.D., Roberts, K.M., Hurst, M.A., Kaine, B.P., Borodovsky, M., Klenk, H.-P., Fraser, C.M., Smith, H.O., Woese, C.R., and Venter, J.C. (1996). Complete genome sequence of the methanogenic Archeon, Methococcus jannaschii. Science. 273: 1058-1073.

Camilli, A., Beattie, D.T., and Mekalanos, J.J. (1994). Use of genetic recombination as a reporter of gene expression. Proc. Natl, Acad. Sci. 91: 2634-2638.

Chan, A., Izutsu, K.T., Belton, C.M., Weinberg, A., and Lamont, R.J. (1995). Characterization of the invasion of gingival epithelial cells by P. gingivalis. J. Dent. Res. 74: Ab. 1510.

Choi, J.I., Nakagawa, T., Yamada, S., Takazoe, I., and Okuda, K. (1990). Clinical, Microbiological and imunlogical studies on recurrent periodontal disease. J. Clin. Periodontol. 17: 426-434.

Ciborowski, P., Nishikata, M., Allen, R.D., and Lantz, M.S. (1994). Purification and characterization of two forms of a high molecular-weight cysteine protease (porphypain) from Porphyromonas gingivalis. J. Bacteriol. 176: 4549-4557.

Curtis, M.A., Slaney, J.M., Carman, R.J., and Johnson, N.W. (1991). Identification of the major surface protein antigens of Porphyromonas gingivalis using IgG antibody reactivity of periodontal case-control serum. Oral Microbiol. Immunol. 6: 321-326.

Cutler, C.W. , Kalmar, J.R., and Genco, C.A. (1995). Pathogenic strategies of the oral anaerobe, Porphyromonas gingivalis. Trends in Microbiology. 3: 45-51.C

Davies, J., (1996). Bacteria on the rampage. Nature, 383:219-220.

Davison, J., Heusterspreute, M., Chevalier, N., Vinh, H-T. and Brunel, F. (1987). Vectors with restriction site banks, V. pJRD215, a wide-host-range cosmid vector with multiple cloning sites. Gene, 51:275-280.

Dickinson, D. P., Kubineic, M. K., Yoshimura, F., and Genco, R. J. (1988). Molecular cloning and sequencing of the gene encoding the fimbrial subunit of Bacteroides gingivalis. J. Bacteriol. 170: 1658-1665.

Duncan, A.J., Carman, R.J.,Harper, F.H., Griffiths, G.S., and Curtis, M.A. (1992). Porphyromonas gingivalis: presence of a species -specific antogen which is discriminatory in chronic inflammatory adult periodontal disease. Microb. Ecol. Health Dis. 5: 15-20.

Duncan, M.J., Nakao, S., Skobe, Z., and Xie, H. (1993). Interactions of Porphyromonas gingivalis with epithelial cells. Infect. and Immun. 61: 2260-2265.

Dusek, D.M., Progulske-Fox, A., Whitlock, J., and Brown, T.A. (1993). Isolation and characterization of a cloned Porphyromonas gingivalis hemagglutinin from an avirulent strain of Salmonella typhimurium. Infect. Immun. 61: 940-946.

Dusek, D.M., Progulske-Fox, A., and Brown, T.A. (1994). Systemic and mucosal immune responses in mice orally immunized with avirulent Salmonella typhimurium expressing a cloned Porphyromonas gingivalis hemagglutinin. Infect. Immun. 62: 1652-1657.

Dusek, D.M., Progulske-Fox, A., and Brown, T.A. (1995). Expression and immunogenicity of a cloned Porphyromonas gingivalis hemagglutinin in Salmonella typhimurium. Advances in Experimental Medicine and Biology. 371B: 1119-1121.

Edwards, A, Voss, H., Rice, P., Civitello, A., Stegemann, J., Schwager, C., Zimmermann, J., Erfle, H., Caskey, C.T., and Ansorge, W. (1990). Automated DNA sequencing of the human HPRT locus. Genomics. 6:593-608.

Evans, R.T., Klausen, B., Sojar, H.T., Bedi, G.S., Sfintescu, C., Ramamurthy, N.S., Golub, L.M., and Genco, R.J. (1992). Immunization with Porphyromonas (Bacteroides) gingivalis fimbriae protects against periodontal detruction. Infect. Immun. 60: 2926-2935.

Fichant, G.A. and Burks, C. (1991). Identifying potential tRNA genes in genomic DNA sequences. J. Mol. Biol. 220:659-671.

Fleischmann, R.D. M. D. Adams, O. White, R. A. Clayton, E. F. Kirkness, A. R. Kerlavage, C. J. Bult, J.-F. Tomb, B. A. Dougherty, J. M. Merrick, K. McKenney, G. Sutton, W. FitzHugh, C. Fields, J. D. Gocayne, J. Scott, R. Shirley, L.-I. Liu, A. Glodek, J. M. Kelley, J. F. Weidman, C. A. Phillips, T. Spriggs, E. Hedblom, M. D. Cotton, T. R. Utterback, M. C. Hanna, D. T. Nguyen, D. M. Saudek, R. C. Brandon, L. D. Fine, J. L. Fritchman, J. L. Fuhrmann, N. S. M. Geoghagen, C. L. Gnehm, L. A. McDonald, K. V. Small, C. M. Fraser, H. O. Smith, J. C. Venter. (1995). Whole-genome random shotgun sequencing and assembly of Haemophilus influenzae Rd. Science 269:496-512.

Fletcher, H.M., Schenkein, H.A., Morgan, R.M., Bailey, K.A., Berry, C.R., and Macrina, F.L. (1995). Virulence of a Porphyromonas gingivalis W83 mutant defective in the prtH gene. Infect. Immnun. 63: 1521-1528.

Fraser, C.M., Gocayne, J.D., White, O., Adams, M.D., Clayton, R.A., Fleischmann, R.D., Bult, C.J., Kerlavage, A.R., Sutton, G., Kelley, J.M., Fritchman, J.L., Weidman, J.F., Small, K.V., Sandusky, M., Fuhrmann, J., Nguyen, D., Utterback, T.R., Saudek, D.M., Phillips, C.A., Merrick, J.M., Tomb, J.-F., Dougherty, B.A., Bott, K.F., Hu, P.-C., Lucier, T.S., Peterson, S.N., Smith, H.O., Hutchison, C.A., and Venter, J.C. (1995). The Mycoplasma genitalium genome sequence reveals a minimal gene complement. Science 270:397-403.

Fraser, G.J. and Duncan, M.J. (1992). Pulsed field gel electrophoresis reveals differences between Porphyromonas gingivalis strains. J. Dent. Res. 71:737, Abstract # 1769.

Fujiwara, T., Morishima, S., Takahashi, I., and Hamada, S. (1993). Molecular cloning and sequencing of the fimbrillin gene of Porphyromonas gingivalis strains and characterization of recombinant proteins. Biochem. Biophys. Res. Commun. 197: 241-247.

Genco, C.A., Cutler, C.W., Kapczynski, D., Maloney, H., and Arnold, RR. (1991). A novel mouse model to study the virulence of and host response to Porphyromonas (Bacteroides) gingivalis. Infect. Immun. 59:1255-63

Genco, C.A., Lassiter, M., Forng, R.Y. and Basil, M.O. (1993). Characterization of Tn4351 generated mutants of Porphyromonas gingivalis. J. Dent. Res. 72: Ab.123.

Genco, C.A., Odusanya, B.M., and Brown, G. (1994). Binding and accumulation of hemin in Porphyromonas gingivalis are induced by hemin. Infect. Immun. 62: 2885-2892.

Genco, C.A., Schifferle, R.E., Njooroge,T., Forng, R,-Y., and Cutler, C.W. (1995a). Resistance of a Tn4351-generated polysaccharide mutant of Porphyromonas gingivalis to polymorphonuclear leucocyte killing. Infect. Immun. 63: 393-401.

Genco, C.A., Simpson, W., Forng, R.Y., Egal, M., Odusanyo, B.M. (1995b). Characterization of a Tn4351-generated hemin uptake mutant of Porphyromonas gingivalis: evidence for the coordinate regulation of virulence factors by hemin. Infect. Immun. 63: 2459-2466.

Gharbia, S.E. and Shah, H.N. (1993). Conjugal transfer of Tn4351 into Prevotella intermedia and Porphyromonas gingivalis. J. Dent. Res. 72: Ab. 2156.

Hafajee, A.D., Dzink, J.L., and Socransky, S.S. (1988). Effect of modified Widman flap surgery and systemic tetracycline on the subgingival microbiota of periodontal lesions. J. Clin. Periodontol. 15: 255-262.

Hafajee, A.D., and Socransky, S.S. (1994) Microbial etiological agents of destructive periodontal diseases. Periodontology 2000. 5: 78-111.

Hamada, N., Watanabe, K.,Sasakawa, C., Yoshikawa, M., Yoshimura, F., and Umemoto,T. (1994). Construction and characterization of a fimA mutant of Porphyromonas gingivalis. Infect. Immun. 62: 1696-1704.

Han, N., Whitlock, J., Patti, J. M., Lantz, M. S. and Progulske-Fox, A. (1993). DNA sequence analysis of a gene encoding a putative fibrinogen and fibronectin binding protein from P. gingivalis. J. Dent. Res. 72: Ab. 418.

Hensel, M., Shea, J.E. Gleeson, C., Jones, M.D., Dalton, E., and Holden, D.W. (1995) Simultaneous identification of bacterial virulence genes by negative selection. Science. 269: 400-403.

Holt, S.C. and Bramanti, T.E. (1991). Factors in Virulence expression and their role in periodontal disease. Crit. Revs. in Oral Biol. and Med. 2: 177-281.

Holt, S.C., Ebersole, J., Felton, J., Brunsvold, M., and Kornman, K.S. (1988). Implantation of Bacteroides gingivalis in nonhuman primates initiates progression of periodontitis. Science. 239: 55-57.

Hoover, C.I., and Yoshimura, F. (1994). Transposon-induced pigment-deficient mutants of Porphyromonas gingivalis. FEMS Microbiol. Lett. 124: 43-48.

Imamura, T., Pike, R.N., Potempa, J., and Travis, J. (1994). Pathogenesis of periodontitis: a major arginine-specific cysteine proteinase from Porphyromonas gingivalis induces vascular permeability enhancement through activation of the kallikrein/kinin pathway. J. Clin. Investig. 94: 361-367.

Isogai, H., Isogai, E., Yoshimura, F., Suzuki,T., Kagota, W. and Takano, K. (1988). Specific inhibition of an oral strain of Bacteroides gingivalis 381 to epithelial cells by monoclonal antibodies against the bacterial fimbriae. Arch. Oral. Biol. 33: 479-485.

Johnson, V., Johnson, B.D., Sims, T.J., Whitney,C.W., Moncla, B.J., and Engel, L.D. (1993). Effects of treatment on antibody titer to Porphyromonas gingivalis in gingival crevicular fluid of patients with rapidly progressive periodontitis. J. Periodontol. 64: 559-565.

Jousimies-Somer, H.R., Summanen, P.H., and Finegold, S.M. (1995). Bacteroides, Porphyromonas, Prevotella, Fusobacterium, and other anaerobic Gram-negative bacteria. In Manual of Clinical Microbiology, 6th ed. (Eds.) Murray, P.R., Baron, J.E., Pfaller, M.A., Tenover, F.C., and Yolken R.H. ASM Press, Washington D.C., pp 603-620.

Karp, P.D. (1992). A knowledge base of the chemical compounds of intermediary metabolism. Comput. Appl. Biosci., 8:347-357.

Karunakaran, T., and Holt, S.C. (1993). Cloning of two distinct hemolysin genes from Porphyromonas (Bacteroides) gingivalis in Escherichia coli. Microbial Path. 15: 37-49.

Kerlavage, A.R., Adams, M.D., Kelley, J.C., Dubnick, M., Powell, J., Shanmugam, P., Venter, J.C., and Fields, C. (1993). Analysis and management of data from high-throughput expressed sequence tag projects. pp. 585-594. From: Proceedings of the Twenty-Sixth Annual Hawaii Internations conference on System Sciences. IEEE Computer Society Press. Washington, D.C.

Kerlavage, A.R., W. FitzHugh, A. Glodek, J. Kelley, J. Scott, R. Shirley, G. Sutton, M. Wai-Chiu, O. White and M. D. Adams. (1995). Data Management and Analysis for High-Throughput DNA Sequencing Projects. IEEE Engineering in Medicine and Biology, 14:710-717.

Killian, M. (1981). Degradation of immunoglobulins A1, A2, and G by suspected periodontal pathogens. Infect. Immun. 34: 757-765.

Lamont, R. J., Oda, D., Persson, R. E. and Persson, G. R. (1992). Interaction of Porphyromonas gingivalis with gingival epithelial cells maintained in culture. Oral Microbiol. Immunol. 7: 364-367.

Lamont, R.J., Chan, A., Belton, C.M., Izutsu, K.T., Vasel, D. and Weinberg, A. (1995). Porphyromonas gingivalis invasion of epithelial cells. Infect. Immun. 63: 3878-3885.

Lantz, M.S., Allen, R.D., Duck, L.W., Blume, J.L., Switalski, L.M., and Hook, M. (1991). Identification of Porphyromonas gingivalis components that mediate its interactions with fibronectin. J. Bacteriol. 173: 4263-4270.

Lander, E.S. and Waterman, M.S. (1988). Genomic mapping by fingerprinting random clones: A mathematical analysis. Genomics. 2:231-239.

Lee, J.J., Smith, H.O., and Redfield, R.R. (1989). The organization of the Haemophilus influenzae Rd genome. J. Bacteriol. 171:3016.

Lee, J.-Y., Sojar, H.T., Bedi, G.S., and Genco, R. J. (1992). Synthetic peptides analogous to the fimbrillin sequence inhibit adherence of Porphyromonas gingivalis. Infect. Immun. 60: 1662-1670.

Lee, J.-Y., Sojar, H.T., Bedi, G.S., and Genco, R.J. . (1993). Active domains of fimbrillin involved in adherence of Porphyromonas gingivalis. J. Perio. Res. 28: 470-472.

Lepine, G., Ellen, R.P. and Progulske-Fox, A. (1996). Construction and Preliminary characterization of three hemagglutinin mutants of Porphyromonas gingivalis. Infect. Immun. 64: (4) 1467-1472.

Leung, M.Y., Blaisdell, B.E., Burge, C., and Karlin, S. (1991). An efficient algorithm for identifying matches with errors in multiple long molecular sequences. J. Mol. Biol. 221:1367-1378.

Loos, B.G., Dyer, D.W., Whittam, T.S., and Selander, R.K. (1993). Genetic structure of populations of Porphyromonas gingivalis associated with periodontitis and other oral infections. Infect. Immun. 61: 204-212.

Lupski, J.R. and Weinstock, G.M. (1992). Short, interspersed repetitive DNA sequences in prokaryotic genomes. J. Bacteriol., 174:4525-4529.

Macrina, F.L. and Smith, C.J. (1993). Gene transmission, MLS, and tetracycline resistance in Bacteroides. In: Genetics and Molecular Biology of Anaerobic Bacteria. Ed. Madeleine Sebald, Springer-Verlag. 474-489.

Madden, T.E., Clark, V.L., and Kuramitsu, H.K. (1995). Revised sequence of the Porphyromonas gingivalis Prt cysteine protease/hemagglutinin gene: homology with streptococcal pyrogenic exotoxin B/ streptococcal proteinase. Infect. Immun. 63: 238-247.

Mahan, M.J., Slauch, J.M., and Mekalanos, J.J. (1993). Selection of bacterial virulence genes that are specifically induced in host tissues. Science. 259: 686-688.

Mahan, M.J., Tobias, J.W., Slauch, J.M., Hanna, P.C., Collier, R.J.. and Mekalanos, J.J. (1995). Antibiotic-based selection for bacterial genes that are specifically induced during infection of a host. Proc. Natl. Acad. Sci. 92: 669-673.

Malek, R., Fisher, J.G., Caleca, A., Stinson, M., Van Oss, C.J., Lee, J.Y., Cho, M.I., Genco, R.J., Evans, R.T. and Dwyer, D.W. (1994). The inactivation of the Porphyromonas gingivalis fimA gene blocks periodontal damage in gnotobiotic rats. J. Bacteriol. 176: 1052-1059.

McBride, B.C., Singh, U., and Joe, A. (1993) Porphyromonas gingivalis: Gene cloning of determinants of pathogenicity. In: Genetics and Molecular Biology of Anaerobic Bacteria. Pp 552-568. Ed: Madeleine Sebald. Springer-Verlag,

McDonald, L.A., Kelley, J.M., Brandon, R.C., and Adams, M.D. (1995). Optimization of Applied Biosystems 373 Sequencer Stretch Modification. BioTechniques 19:464-471.

Menard, C., and Mouton, C. (1995). Clonal diversity of the taxon Porphyromonas gingivalis assessed by random amplified polymorphic DNA fingerprinting. Infect. Immun. 63: 2522-2531.

Moore, W.E.C., Moore, L.H., Ranney, R.R., Smibert, R.M., Burmeister, J.A., and Schenkein, H.A. (1991) The microflora of periodontal sites showing active destructive progression. J. Clin. Periodontol. 18: 729-739.

Mouton, C., Deslauries, M., Allard, H., and Bouchard, M. (1987). Serum antibodies to Bacteroides gingivalis in periodontitis: a longitudinal study. J. Periodont. Res. 22: 426-430.

Murray, P.A., Burstein, D.A., and Winkler, J.R. (1989). Antibodies to Bacteroides gingivalis in patients with treated and untreated periodontal disease. J. Periodontol. 60: 96-103.

Nakayama K., Kadowaki, T., Okamoto, K., and Yamamoto, K. (1995). Construction and characterization of arginine-specific cysteine protease (arg-gingipain)-deficient mutants of Porphyromonas gingivalis. Evidence for significant contribution of arg-gingipain to virulence. J. Biol. Chem. 270: 23619-23626.

Neiders, M.E., Chen, P.B., Reynolds, H.S., Zambon, J.J., and Genco, R.J. (1989). Heterogenicity of virulence among strains of Bacteroides gingivalis. J. Periodontal Res. 24:192-198.

Neville, B.W., Damm, D.D., Allen, C.M., and Bouquot, J.E. (1995). In: Oral and Maxillofacial Pathology. 1st. Edition. W.B.Saunders Co. p.134..

Nikolich, M.P., Shoemaker, N.B., and Salyers, A.A. (1992). A Bacteroides tetracycline resistance gene represents a new class of ribosome protection tetracycline resistance. Antimicrob. Agents chemother. 36: 1005-1012.

Ogawa, T., Kono, Y., McGhee. M.L., McGhee, J.R., Roberts, J.E., Hamada, S, and Kiyono, H. (1991). Porphyromonas gingivalis-specific serum IgG and IgA antibodies originate from immunoglobin-secreting cells in inflamed gingiva. Clin. Exp. Immunol. 83: 237-244.

Papapanou, P.N., Sandros, J., Lindberg, K., Duncan, M.J., Niederman, R. and Nannmark, U. (1994). Porphyromonas gingivalis may multiply and advance within stratified human junctional epithelium in vitro. J. Periodont. Res. 29: 374-375.

Park, Y., and McBride, B. C. (1993). Characterization of the tpr gene product and isolation of a specific protease-deficient mutant of Porphyromonas gingivalis W83. Infect. Immun. 61:4139-4146.

Paster, B.J., Dewhirst, F.E., Olsen, I., and Fraser, G.J. (1994). Phylogeny of Bacteroides, Prevotella, and Porphyromonas spp. and related bacteria. J. Bacteriol. 176:725-732.

Pavloff, N., Potempa, J., Pike, R.N., Prochazka, V., Kiefer, C., Travis, J., and Barr, P.J. (1995). Molecular cloning and structural characterization of the arg-gingipain of Porphyromonas gingivalis, biosynthesis as a proteinase- adhesin polyprotein. J. Biol. Chem. 270: 1007-1010.

Pearson, W. and Lipman, J. (1988). Improved tools for biological sequence comparison. Proc. Natl. Acad. Sci. USA. 85:2444-2448.

Persson, G.R., D. Engel, C. Whitney, R. Darveau, A. Weinberg, M. Brunsvold, and R.C. Page. (1994). Immunization against porphyromonas gingivalis inhibits progression of experimental periodontitis in nonhuman primates. Infect. immunity 62:1026-1031.

Potempa, J., Pavloff, N., and Travis, J. (1995). Porphyromonas gingivalis: a proteinase/gene accounting audit. Trends Microbiol, 3: 430-434.

Rasmussen, B.A., Bush, K., Tally, F.P. (1993). Antimicrobial resistance in Bacteroides. Clin Infectious Diseases 16(Suppl 4):S390-400.

Rasmussen, J.L., Odelson, D.A., and Macrina, F.L. (1987). Complete nucleotide sequence of Insertion element IS4351 from Bacteroides fragilis. J. Bacteriol. 169: 3573-3580.

Reynolds, H.S., Van Winkelhoff, A.J., Schifferle, R.E., Chen, P.B., and Zambon, J.J. (1989). Relationship of encapsulation of Bacteroides gingivalis to invasiveness. J. Dent. Res. 68: (Special Issue). 328.

Riley, M. (1993). Functions of the gene products of Escherichia coli. Microbiol. Rev. 57:862-952.

Rosenshine, I., S. Ruschkowski, V. Foubister, and B. B. Finlay. (1994). Salmonella typhimurium invasion of epithelial cells: Role of induced host cell tyrosine protein phosphorylation. Infect. Immun. 62: 4969-4974.

Salyers, A.A. and Shoemaker, N.N. (1992). Chromosomal gene transfer elements of the Bacteroides group. European. J. Clin. Microbiol. and Infect. Dis. 11: 1032-1038.

Sandros, J., Papapanou, P. N. and Dahlen, G. (1993). Porphyromonas gingivalis invades oral epithelial cells in vitro. J. Periodont. Res. 28: 219-226.

Sandros, J., Papapanou, P. N., Nannmark, U. and Dahlen, G. (1994). Porphyromonas gingivalis invades human pocket epithelium in vitro. J. Periodont. Res. 29: 62-69.

Schenkein, H. (1988). The effect of periodontal proteolytic Bacteroides spp. on proteins of the human complement system. J. Periodont. Res. 23: 187-192.

Schifferle, R.E., Chen, P.B., Davern, L.B., Aguirre, A., Genco, R.J., Levine, M.J. (1993). Modification of experimental Porphyromonas gingivalis murine infection by immunization with a polysaccharide-protein conjugate. Oral Microbiol. Immunol. 8: 266-271.

Selkov, E. (1994). Database on enzymes and metabolic pathways of Escherichia coli. Third International E. coli Genome Meeting, Woods Hole, MA.

Shoemaker, N. B., Barber, R. D., and Salyers, A. A. (1989). Cloning and characterization of a Bacteroides conjugal tetracycline-erythromycin resistance element by using a shuttle cosmid vector. J. Bacteriol. 171: 1294-1302.

Slots, J., and Hausmann, E. (1979). Logitudinal study of experimentally induced periodontal disease in Macaca arctoides: relationship between microflora and alveolar bone loss. Infect. Immun. 23: 260-269.

Speigel, C.A., Hayduk, S.E., Minah, G.E., and Krywolap, G.N. (1979). Black pigmented Bacteroides from clinically characterized periodontal sites. J. Periodont. Res. 14: 376-382.

Sundqvist, G., Figdor, D., Hanstrom, L., Sorlin, S., Sandstrom, G. (1991). Phagocytosis and virulence of different strains of Porphyromonas gingivalis. Scand. J. Dent. Res. 99: 117-129.

Sutton, G.G., White, O., Adams, M.D., and Kerlavage, A.R. (1995). TIGR Assembler: A new tool for assembling large shotgun sequencing projects. Genome Science and Technology, 1:9-19.

Svanberg, G.K., Syed, S.A., and Scott, B.W. Jr. (1982). Differences between gingivitis and periodontitis associated microbial flora in the beagle dog. Relationship between plaque parameters to histological parameters of periodontal disease. J. Periodont. Res. 17: 1-11.

Tally, F.P., Snydman, D.R., Shimell, M.J., and Malamy, M.H. (1982) Characterization of pBFTM10, a clindamycin-erythromycin resistance transfer factor from Bacteroides fragilis. J. Bacteriol. 151:686-691.

Utterback, T.R., McDonald, L.A., and Fuldner, R.A. (1995) A reliable, efficient protocol for 96-well plasmid DNA miniprep with rapid DNA quantification for high throughput automated DNA sequencing. . Genome Science and Technology 1:1-8.

Van Winkelhoff, A.J., Appelmelk, B.J., Kippuw, N., de Graaf, J. (1993). K-Antigens in Porphyromonas gingivalis are associated with virulence. Oral. Microbiol. Immunol. 8: 259-265.

Versalovic, J., Kapur, V., Keouth, T., Mazurek, G.H., Whittam, T.S., Musser, J.M., Lupski, J.R. (1995). DNA fingerprinting of pathogenic bacteria by fluorophore-enhanced repetitive sequence-based polymerase chain reaction. Arch. Pathol. Lab. Med., 119:23-29.

Watanabe, K., Yamaji, Y. and Umemoto, T. (1992). Correlation between cell-adherent activity and surface structure in Porphyromonas gingivalis. Oral Microbiol. Immunol. 7: 357-363.

Waterman, M.S. (1988). Computer analysis of nucleic acid sequences. Methods Enzymol. 164:765-793.

Welch, J. and McClelland, M. (1991). Genomic fingerprints produced by PCR with consensus rRNA gene primers. Nucl. Acids Res. 19:861-866.

White, O., Dunning, T., Sutton, G., Adams, M., Venter J.C., and Fields, C. (1993). A quality control algorithm for DNA sequencing projects. Nucleic Acids Research. 21:3829-3838.

Woese, C.R., (1987). Bacterial evolution. Microbiol. Rev. 51:221-271.

Yoshimoto, H., Takahashi, Y., Hamada, N. and Umemoto, T. (1993) Genetic transformation of Porphyromonas gingivalis by electroporation. Oral Microbiol. Immunol. 8:208-212.

Zambon, J.J., Reynolds, H.S., and Slots,J. (1981). Black-pigmented Bacteroides spp. in the human oral cavity. Infect. Immun. 32: 198-203.

Zambon, J.J., Bochacki, V., and Genco, R.J. (1986). Immunological assays for putative periodontal pathogens. Oral Microbiol. Immunol. 1: 39-47.

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